Imaging integrin αvβ3 on blood vessels with 111In-RGD2 in head and neck tumor xenografts.
Identifieur interne : 000151 ( Main/Exploration ); précédent : 000150; suivant : 000152Imaging integrin αvβ3 on blood vessels with 111In-RGD2 in head and neck tumor xenografts.
Auteurs : RBID : pubmed:24408894English descriptors
- KwdEn :
- Animals, Blood Vessels (metabolism), Carcinoma, Squamous Cell (blood supply), Carcinoma, Squamous Cell (metabolism), Carcinoma, Squamous Cell (radionuclide imaging), Cell Line, Tumor, Female, Head and Neck Neoplasms (blood supply), Head and Neck Neoplasms (metabolism), Head and Neck Neoplasms (radionuclide imaging), Immunohistochemistry, Indium Radioisotopes (chemistry), Integrin alphaVbeta3 (metabolism), Mice, Mice, Inbred BALB C, Neoplasm Transplantation, Neovascularization, Pathologic, Oligopeptides (chemistry), Radiopharmaceuticals (chemistry), Tomography, Emission-Computed, Single-Photon (methods), Tomography, X-Ray Computed (methods).
- MESH :
- chemical , chemistry : Indium Radioisotopes, Oligopeptides, Radiopharmaceuticals.
- blood supply : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- metabolism : Blood Vessels, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Integrin alphaVbeta3.
- methods : Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
- radionuclide imaging : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- Animals, Cell Line, Tumor, Female, Immunohistochemistry, Mice, Mice, Inbred BALB C, Neoplasm Transplantation, Neovascularization, Pathologic.
Abstract
Arginine-glycine-aspartic acid (RGD)-based imaging tracers allow specific imaging of integrin αvβ3, a protein overexpressed during angiogenesis, leading to the possibility that it might serve as a tool to stratify patients for antiangiogenic treatment. However, these tracers have generally been characterized in xenograft models in which integrin αvβ3 was constitutively expressed by the tumor cells themselves. In the studies presented here, the use of (111)In-RGD2 as a tracer to image only integrin αvβ3 expression on blood vessels in the tumor was determined using tumor xenografts in which tumor cells were integrin αvβ3-negative.
DOI: 10.2967/jnumed.113.129668
PubMed: 24408894
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Imaging integrin αvβ3 on blood vessels with 111In-RGD2 in head and neck tumor xenografts.</title><author><name sortKey="Terry, Samantha Y A" uniqKey="Terry S">Samantha Y A Terry</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Radboud UMC, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Nuclear Medicine, Radboud UMC, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Abiraj, Keelara" uniqKey="Abiraj K">Keelara Abiraj</name></author><author><name sortKey="Frielink, Cathelijne" uniqKey="Frielink C">Cathelijne Frielink</name></author><author><name sortKey="Van Dijk, Laura K" uniqKey="Van Dijk L">Laura K van Dijk</name></author><author><name sortKey="Bussink, Johan" uniqKey="Bussink J">Johan Bussink</name></author><author><name sortKey="Oyen, Wim J" uniqKey="Oyen W">Wim J Oyen</name></author><author><name sortKey="Boerman, Otto C" uniqKey="Boerman O">Otto C Boerman</name></author></titleStmt><publicationStmt><date when="2014">2014</date><idno type="RBID">pubmed:24408894</idno><idno type="pmid">24408894</idno><idno type="doi">10.2967/jnumed.113.129668</idno><idno type="wicri:Area/Main/Corpus">000217</idno><idno type="wicri:Area/Main/Curation">000217</idno><idno type="wicri:Area/Main/Exploration">000151</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Blood Vessels (metabolism)</term><term>Carcinoma, Squamous Cell (blood supply)</term><term>Carcinoma, Squamous Cell (metabolism)</term><term>Carcinoma, Squamous Cell (radionuclide imaging)</term><term>Cell Line, Tumor</term><term>Female</term><term>Head and Neck Neoplasms (blood supply)</term><term>Head and Neck Neoplasms (metabolism)</term><term>Head and Neck Neoplasms (radionuclide imaging)</term><term>Immunohistochemistry</term><term>Indium Radioisotopes (chemistry)</term><term>Integrin alphaVbeta3 (metabolism)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neoplasm Transplantation</term><term>Neovascularization, Pathologic</term><term>Oligopeptides (chemistry)</term><term>Radiopharmaceuticals (chemistry)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tomography, X-Ray Computed (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Indium Radioisotopes</term><term>Oligopeptides</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Blood Vessels</term><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term><term>Integrin alphaVbeta3</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Female</term><term>Immunohistochemistry</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neoplasm Transplantation</term><term>Neovascularization, Pathologic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Arginine-glycine-aspartic acid (RGD)-based imaging tracers allow specific imaging of integrin αvβ3, a protein overexpressed during angiogenesis, leading to the possibility that it might serve as a tool to stratify patients for antiangiogenic treatment. However, these tracers have generally been characterized in xenograft models in which integrin αvβ3 was constitutively expressed by the tumor cells themselves. In the studies presented here, the use of (111)In-RGD2 as a tracer to image only integrin αvβ3 expression on blood vessels in the tumor was determined using tumor xenografts in which tumor cells were integrin αvβ3-negative.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24408894</PMID><DateCreated><Year>2014</Year><Month>02</Month><Day>04</Day></DateCreated><DateCompleted><Year>2014</Year><Month>04</Month><Day>08</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1535-5667</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><Issue>2</Issue><PubDate><Year>2014</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Journal of nuclear medicine : official publication, Society of Nuclear Medicine</Title><ISOAbbreviation>J. Nucl. Med.</ISOAbbreviation></Journal><ArticleTitle>Imaging integrin αvβ3 on blood vessels with 111In-RGD2 in head and neck tumor xenografts.</ArticleTitle><Pagination><MedlinePgn>281-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2967/jnumed.113.129668</ELocationID><Abstract><AbstractText Label="UNLABELLED">Arginine-glycine-aspartic acid (RGD)-based imaging tracers allow specific imaging of integrin αvβ3, a protein overexpressed during angiogenesis, leading to the possibility that it might serve as a tool to stratify patients for antiangiogenic treatment. However, these tracers have generally been characterized in xenograft models in which integrin αvβ3 was constitutively expressed by the tumor cells themselves. In the studies presented here, the use of (111)In-RGD2 as a tracer to image only integrin αvβ3 expression on blood vessels in the tumor was determined using tumor xenografts in which tumor cells were integrin αvβ3-negative.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">DOTA-E-[c(RGDfK)]2 was radiolabeled with (111)In ((111)In-RGD2), and biodistribution studies were performed in squamous cell carcinoma of the head and neck (HNSCC) xenograft mouse models to determine the optimal peptide dose to image angiogenesis. Next, biodistribution and imaging studies were performed at the optimal peptide dose in 3 HNSCC mouse models, FaDu, SCCNij3, and SCCNij202. Immunohistochemical analysis of tumor vascular and cell surface expression of integrin αvβ3 and correlation analysis of vascular integrin αvβ3 and autoradiography were completed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">All 3 HNSCC xenografts expressed integrin αvβ3 on the vessels only. The optimal peptide dose of (111)In-RGD2 was 1 μg or less for specific integrin αvβ3-mediated uptake of the tracer. SPECT/CT imaging showed clear uptake of the tracer in the periphery of the tumors, corresponding with well-vascularized areas of the tumor. Within the tumor, (111)In-RGD2 autoradiography coincided with vascular integrin αvβ3 expression, as determined immunohistochemically. Integrin αvβ3-mediated uptake was also detected in nontumor tissues, which, through immunohistochemical analysis, proved positive for integrin αvβ3.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">(111)In-RGD2 allows the visualization of integrin αvβ3 in xenograft models in which integrin αvβ3 is expressed only on the neovasculature, such as in the HNSCC tumors. Thus, (111)In-RGD2 allows specific visualization of angiogenesis in tumor models lacking constitutive tumoral integrin αvβ3 expression but may be less useful for this purpose in many tumors in which tumor cells express integrin αvβ3.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Terry</LastName><ForeName>Samantha Y A</ForeName><Initials>SY</Initials><Affiliation>Department of Nuclear Medicine, Radboud UMC, Nijmegen, The Netherlands.</Affiliation></Author><Author ValidYN="Y"><LastName>Abiraj</LastName><ForeName>Keelara</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Frielink</LastName><ForeName>Cathelijne</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>van Dijk</LastName><ForeName>Laura K</ForeName><Initials>LK</Initials></Author><Author ValidYN="Y"><LastName>Bussink</LastName><ForeName>Johan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Oyen</LastName><ForeName>Wim J</ForeName><Initials>WJ</Initials></Author><Author ValidYN="Y"><LastName>Boerman</LastName><ForeName>Otto C</ForeName><Initials>OC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nucl Med</MedlineTA><NlmUniqueID>0217410</NlmUniqueID><ISSNLinking>0161-5505</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Integrin alphaVbeta3</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Oligopeptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>99896-85-2</RegistryNumber><NameOfSubstance>arginyl-glycyl-aspartic acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Blood Vessels</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName><QualifierName MajorTopicYN="N">blood supply</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Head and Neck Neoplasms</DescriptorName><QualifierName MajorTopicYN="N">blood supply</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Integrin alphaVbeta3</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neoplasm Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Neovascularization, Pathologic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Oligopeptides</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tomography, Emission-Computed, Single-Photon</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SPECT imaging</Keyword><Keyword MajorTopicYN="N">angiogenesis</Keyword><Keyword MajorTopicYN="N">dimeric RGD</Keyword><Keyword MajorTopicYN="N">head and neck carcinoma</Keyword><Keyword MajorTopicYN="N">integrin αvβ3</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>1</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24408894</ArticleId><ArticleId IdType="pii">jnumed.113.129668</ArticleId><ArticleId IdType="doi">10.2967/jnumed.113.129668</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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